You can’t apply for an H-1B through your own company. If you are from an E-2 treaty country, you can apply for an E-2 visa and then later convert to an EB-5. It is important you obtain EB-5 counsel to advise in this type of complex case.
Your regional center application must be supported by hypothetical or actual EB-5 projects in the geographical area and business activities you wish to cover and be involved with. The geographical area could cover multiple states if your project (or projects) can support such a request.
First it is advisable to seek the services and advise of a qualified and experienced EB-5 attorney in the preparation and filing of an EB-5 regional center application. Second, depending on the actual location of the business activities of the new commercial enterprise and job creating entity the regional center may cover geography in more than one state as long as the area consists of contiguous counties.